Diphenhydramine help

BitterDB id=61 , Synthetic
Detailed experimental validation described in the associated resource.

References for the compound bitterness help

Resource Comment
[1] Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913
[2] Roland W. S. U. et al. Soy Isoflavones and Other Isoflavonoids Activate the Human Bitter Taste Receptors hTAS2R14 and hTAS2R39, Journal of Agricultural and Food Chemistry, 2011, 59 (21), 11764-11771 PubMed 21942422
[3] Liu K. et al. Plasticity of the ligand binding pocket in the bitter taste receptor T2R7, Biochimica et Biophysica Acta (BBA) - Biomembranes, 2018, 1860, 5, 991-999 PubMed 29355483
[4] Kumar P. Bitter taste receptors of the zebra finch (Taeniopygia guttata), Frontiers in Physiology, 2023, 4, 14, 1233711 PubMed 37860623
[5] Merck Index Monograph Number: 3309

Known bitter receptors targets: help

Receptor Name Effective concentration (μM) EC50 (μM) References
Human  hTas2r7 634.0 PubMed:29355483
Human  hTas2r14 30.0 PubMed:20022913
Human  hTas2r40 30.0 PubMed:20022913
Chicken  ggTas2r1 10.0 PubMed:25180257

Sensory data about the compound bitterness: help

There is no sensory data available

Properties: help

255.3600 [g/mol] 3.35420
0 2
2 2
6
390 [mg/kg B.W.]

Identifiers: help

58-73-1
C17H21NO
ZZVUWRFHKOJYTH-UHFFFAOYSA-N

Links:

[1] 3100
[2] ZINC000000020244
[3] DB01075
[4] 1224