Propylthiouracil 
BitterDB id=120 , Synthetic
Detailed experimental validation described in the associated resource.
References for the compound bitterness
| Resource | Comment | |
|---|---|---|
| [1] | Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, et al. (2008). Bitter taste receptors influence glucose homeostasis. PLoS One 3(12): e3974. PubMed 19092995 | |
| [2] | Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010). The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 35(2): 157-70. PubMed 20022913 | |
| [3] | Sandau M. M. et al. A functional comparison of the domestic cat bitter receptors Tas2r38 and Tas2r43 with their human orthologs, BMC Neuroscience, 2015, 16(33) PubMed 26037485 | |
| [4] | Lei W. et al. Functional Analyses of Bitter Taste Receptors in Domestic Cats (Felis catus), PLOS ONE, 2015, 10(10) PubMed 26488302 | |
| [5] | Lu Q. et al. Molecular evolution and deorphanization of bitter taste receptors in a vampire bat, Integrative Zoology, 2021, 16(5), 659-669 PubMed 33289344 | |
| [6] | Behrens M. et al. At the Root of T2R Gene Evolution: Recognition Profiles of Coelacanth and Zebrafish Bitter Receptors, Genome Biology and Evolution, 2021, 13(1) PubMed 33355666 | |
| [7] | Shimizu T. et al. Expression profiles and functional characterization of common carp (Cyprinus carpio) T2Rs, Biochemistry and Biophysics Reports, 2021, 28, 101123 PubMed 34504956 | |
| [8] | Cui M. et al. Activation of specific bitter taste receptors by olive oil phenolics and secoiridoids, Sci Rep, 2021, 11, 22340 PubMed 34785711 | |
| [9] | Nolden A. A. Variation in TAS2R receptor genes explains differential bitterness of two common antibiotics, Frontiers in Genetics, 2022, 13 PubMed 35967977 | |
| [10] | Lang T. et al. Activation Profile of TAS2R2, the 26th Human Bitter Taste Receptor, Molecular Nutrition & Food Research, 2023, 67(11) PubMed 36929150 | |
| [11] | Karolkowski A. et al. Non-Volatile Compounds Involved in Bitterness and Astringency of Pulses: A Review, Molecules, 2023, 28(8), 3298 PubMed 37110532 | |
| [12] | Rosa A. et al. Sex Differences in the Bitterness Perception of an Aromatic Myrtle Bitter Liqueur and Bitter Compounds, Nutrients, 2023, 15(9), 2030 PubMed 37432169 | |
| [13] | Nguyen H. et al. Thiazolidinediones are partially effective bitter blockers, bioRxiv, 2023 PubMed 37609224 | |
| [14] | Merck Index Monograph Number: 7869 |
Known bitter receptors targets:
| Receptor Name | Effective concentration (μM) | EC50 (μM) | References |
|---|---|---|---|
hTas2r2 |
3000.0 | PubMed:36929150 | |
|
hTas2r38 |
0.11 | PubMed:20022913 | |
|
hTas2r38 |
30.0 | 2.2 | PubMed:26037485 |
|
hTas2r38 |
1000.0 | PubMed:34785711 | |
|
hTas2r38 |
0.06 | 2.1 | PubMed:37110532 |
mTas2r105 |
300 | PubMed:27226572 | |
|
mTas2r108 |
1000 | PubMed:27226572 | |
|
mTas2r120 |
300 | PubMed:27226572 | |
|
mTas2r121 |
300 | PubMed:27226572 | |
|
mTas2r135 |
300 | PubMed:27226572 | |
|
mTas2r137 |
1000 | PubMed:27226572 | |
fcTas2r2 |
1000.0 | PubMed:26488302 | |
|
fcTas2r4 |
1000.0 | PubMed:26488302 | |
droTas2r408 |
1000.0 | PubMed:33289344 | |
dreTas2r3a |
1000.0 | PubMed:33355666 | |
|
ccarpTas2r200-1 |
1000.0 | PubMed:34504956 | |
|
ccarpTas2r200-2 |
1000.0 | PubMed:34504956 | |
|
ccarpTas2r201 |
1000.0 | PubMed:34504956 | |
|
ccarpTas2r203-1 |
1000.0 | PubMed:34504956 |
Sensory data about the compound bitterness:
| Sensory Data Type | Value | Reference |
|---|---|---|
| Bitter recognition threshold | 0.0107 [mM] | Reference |
Properties:
| 170.2400 [g/mol] | 1.38499 |
| 2 | 2 |
| 1 | 1 |
| 2 |
Identifiers:
| 51-52-5 |
| C7H10N2OS |
|
|
|
|
|
|
| KNAHARQHSZJURB-UHFFFAOYSA-N |
Links:
| [1] | 657298 | ||
| [2] | ZINC000004640636 | ||
| [3] | DB00550 | ||
| [4] | 6650 |
