BitterDB

Please scroll down to see the rest of the ligands.

Download SDF file of selected compounds.

Here are links to the 3D structures of the receptors. If an experimental structure is available, it is recommended to use the RCSB PDB link. Otherwise, you can use the computationally predicted AlphaFold 3D model.

RCSB PDB: link

AlphaFold: link

When using this 2D protein diagram,please cite us:
Ayana Wiener; Marina Shudler; Anat Levit; Masha Y. Niv. BitterDB: a database of bitter compounds. Nucleic Acids Res 2012, 40(Database issue):D413-419.
Click here to view the paper: BitterDB paper

Receptor	Location	BW number	Residue	MAF	dbSNP
TAS2R16	EC2		N172K	0.0883	rs846664
TAS2R16	IC3		R222H	0.2708	rs860170

Receptor	Location	BW number	Residue	References
hTAS2R16	TM1	1.38	I13	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM1	1.39	Y14	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM1	1.46	I21	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM1	1.49	Q24	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.39	V45	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.40	D46	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.42	I48	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.45	S51	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.49	S55	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.50	R56	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.52	C58	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.53	L59	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.54	Q60	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM2	2.55	W61	doi: 10.1038/s41598-017-07256-y
hTAS2R16	EC1	2.58	M64	doi: 10.1038/s41598-017-07256-y
hTAS2R16	EC1	2.71	V77	doi: 10.1038/s41598-017-07256-y
hTAS2R16	EC1	2.73	C79	doi: 10.1038/s41598-017-07256-y
hTAS2R16	EC1	3.28	L81	doi: 10.1038/s41598-017-07256-y
hTAS2R16	EC1	3.29	T82	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.30	I83	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.32	W85	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.33	E86	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R16	TM3	3.35	F88	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.36	N89	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.37	I90	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.40	F93	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.41	W94	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.42	L95	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.44	S97	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.48	V101	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.50	Y103	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM3	3.51	C104	doi: 10.1038/s41598-017-07256-y
hTAS2R16	ICL2	4.36	L118	doi: 10.1038/s41598-017-07256-y
hTAS2R16	ICL2	4.40	I122	doi: 10.1038/s41598-017-07256-y
hTAS2R16	ICL2	4.42	R124	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM4	4.47	I129	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM4	4.52	L134	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM4	4.61	P143	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM4	4.62	S144	doi: 10.1038/s41598-017-07256-y
hTAS2R16	EC2	4.66	N148	doi: 10.1038/s41598-017-07256-y
hTAS2R16	EC2	5.34	N172	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.39	Q177	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R16	TM5	5.43	H181	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005
hTAS2R16	TM5	5.45	V183	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.46	A184	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.47	L185	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.48	V186	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.50	P188	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.51	F189	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.53	L191	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.61	L199	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.62	M200	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM5	5.65	L203	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM6	6.37	L226	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM6	6.40	L229	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM6	6.47	F236	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM6	6.52	F240	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1371/journal.pone.0064675
hTAS2R16	TM6	6.54	I243	doi: 10.1021/acs.jctc.5b00472 doi: 10.1016/bs.mcb.2015.10.005 doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM6	6.55	L244	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM6	6.56	I245	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.34	W257	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.35	L258	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.38	W261	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.39	E262	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.42	V265	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.43	Y266	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.48	M271	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.50	S273	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.52	S275	doi: 10.1038/s41598-017-07256-y
hTAS2R16	TM7	7.53	L276	doi: 10.1038/s41598-017-07256-y
hTAS2R16	C-Term	7.61	K284	doi: 10.1038/s41598-017-07256-y

Receptor	Location	BW number	Residue	MAF	dbSNP
hTAS2R16		0.00	A221V	0.0000	rs28371579
hTAS2R16		0.00	F240V	0.0000	rs28371581
hTAS2R16		0.00	I114V	0.0000	rs28371574
hTAS2R16		0.00	L116P	0.0000	rs28371575
hTAS2R16	EC2	0.00	N172K	0.0883	rs846664
hTAS2R16		0.00	N216D	0.0000	rs28371578
hTAS2R16		0.00	P161S	0.0000	rs28371576
hTAS2R16		0.00	Q177P	0.0000	rs28371577
hTAS2R16	IC3	0.00	R222H	0.2708	rs860170
hTAS2R16		0.00	V101M	0.0000	rs28371571
hTAS2R16		0.00	V235M	0.0000	rs28371580

UniProt	Q9NYV7
GPCRDB	t2r16_human
GeneCards	TAS2R16
The Human Protein Atlas	ENSG00000128519-TAS2R16
IUPHAR/BPS	link

	Diphenidol
	Sodium Benzoate
	D-Amygdalin,Amygdalin
	Arbutin
	Helicin
	Sinigrin
	Gentiobiose
	Linamarin
	D-Salicin,Salicin
	Phenyl beta-D-glucopyranoside
	2-Heptyl-3-hydroxy-quinolone
	esculine Aesculin,Esculine,Aesculin
	2-Naphthyl beta-D-glucopyranoside
	Methyl beta-D-glucoside
	Phenyl beta-D-galactopyranoside
	phenyl alpha-D-glucopyranoside
	2-nitro phenyl beta-D-glucopyranoside
	Soyasaponin I,Soyasaponin Î²b
	Vicine
	Phenyl-beta-D-thioglucopyranoside
	4-nitrophenyl-beta-D-mannopyranoside
	Hexyl-beta-D-glucopyranoside
	Phenyl-N-acetyl-beta-D-glucosaminide
	4-nitrophenyl-beta-D-glucoside,4-Nitrophenyl beta-D-glucopyranoside
	Glucoputranjivin
	Prunasin
	4-Glucosyloxymandelonitrile
	Osmaronin epoxide

BitterDB

hTAS2R16 - Human (Homo sapiens) Taste Receptor Type 2 Member 16

Links and Citations:

Properties

Known Ligands

Experimental/ Computational 3D structures

Protein Diagram

SNPs Table

Known Mutations Table

Known SNP Table